Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis. [electronic resource]
Producer: 20200623ISSN:- 1098-5514
- Animals
- Cell Line
- Coronavirus -- metabolism
- Coronavirus Infections -- metabolism
- Coronavirus Papain-Like Proteases
- HEK293 Cells
- Humans
- Immunity, Innate -- immunology
- Interferon Type I -- metabolism
- Mice
- Murine hepatitis virus -- genetics
- Papain -- genetics
- Peptide Hydrolases -- metabolism
- Protein Domains
- Temperature
- Viral Nonstructural Proteins -- genetics
- Virulence Factors -- metabolism
- Virus Replication -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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