Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis.

Deng, Xufang

Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis. [electronic resource] - Journal of virology 06 2019

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1098-5514

10.1128/JVI.02140-18 doi


Animals
Cell Line
Coronavirus--metabolism
Coronavirus Infections--metabolism
Coronavirus Papain-Like Proteases
HEK293 Cells
Humans
Immunity, Innate--immunology
Interferon Type I--metabolism
Mice
Murine hepatitis virus--genetics
Papain--genetics
Peptide Hydrolases--metabolism
Protein Domains
Temperature
Viral Nonstructural Proteins--genetics
Virulence Factors--metabolism
Virus Replication--genetics