Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice. [electronic resource]
Producer: 20190708Description: 18-28 p. digitalISSN:- 1558-1497
- Alzheimer Disease -- genetics
- Amyloid beta-Peptides -- metabolism
- Animals
- Autophagy
- Brain -- metabolism
- Cognitive Dysfunction -- genetics
- Disease Models, Animal
- Gene Expression
- Genetic Therapy -- methods
- Genetic Vectors -- administration & dosage
- Glucuronidase -- administration & dosage
- Humans
- Injections, Intraventricular
- Klotho Proteins
- Lentivirus
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Microglia -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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