Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice.
Zeng, Chen-Ye
Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice. [electronic resource] - Neurobiology of aging 06 2019 - 18-28 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1558-1497
10.1016/j.neurobiolaging.2019.02.003 doi
Alzheimer Disease--genetics
Amyloid beta-Peptides--metabolism
Animals
Autophagy
Brain--metabolism
Cognitive Dysfunction--genetics
Disease Models, Animal
Gene Expression
Genetic Therapy--methods
Genetic Vectors--administration & dosage
Glucuronidase--administration & dosage
Humans
Injections, Intraventricular
Klotho Proteins
Lentivirus
Male
Mice, Inbred C57BL
Mice, Transgenic
Microglia--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
TOR Serine-Threonine Kinases--antagonists & inhibitors
Up-Regulation
Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice. [electronic resource] - Neurobiology of aging 06 2019 - 18-28 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1558-1497
10.1016/j.neurobiolaging.2019.02.003 doi
Alzheimer Disease--genetics
Amyloid beta-Peptides--metabolism
Animals
Autophagy
Brain--metabolism
Cognitive Dysfunction--genetics
Disease Models, Animal
Gene Expression
Genetic Therapy--methods
Genetic Vectors--administration & dosage
Glucuronidase--administration & dosage
Humans
Injections, Intraventricular
Klotho Proteins
Lentivirus
Male
Mice, Inbred C57BL
Mice, Transgenic
Microglia--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
TOR Serine-Threonine Kinases--antagonists & inhibitors
Up-Regulation