CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations. [electronic resource]
Producer: 20190403Description: 1136 p. digitalISSN:- 2041-1723
- CRISPR-Associated Protein 9 -- genetics
- CRISPR-Cas Systems
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Clustered Regularly Interspaced Short Palindromic Repeats
- DNA -- genetics
- DNA Breaks, Double-Stranded
- Deoxyribonuclease I -- genetics
- Fibroblasts -- cytology
- Gene Editing -- methods
- Genetic Therapy -- methods
- Genome, Human
- HEK293 Cells
- High-Throughput Nucleotide Sequencing
- Humans
- K562 Cells
- Models, Biological
- Porphyria, Erythropoietic -- genetics
- Primary Cell Culture
- RNA, Guide, CRISPR-Cas Systems -- genetics
- Recombinational DNA Repair
- Tumor Suppressor Protein p53 -- genetics
- Uroporphyrinogen III Synthetase -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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