CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.
Cullot, Grégoire
CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations. [electronic resource] - Nature communications Mar 2019 - 1136 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-09006-2 doi
CRISPR-Associated Protein 9--genetics
CRISPR-Cas Systems
Chromosome Deletion
Chromosomes, Human, Pair 10
Clustered Regularly Interspaced Short Palindromic Repeats
DNA--genetics
DNA Breaks, Double-Stranded
Deoxyribonuclease I--genetics
Fibroblasts--cytology
Gene Editing--methods
Genetic Therapy--methods
Genome, Human
HEK293 Cells
High-Throughput Nucleotide Sequencing
Humans
K562 Cells
Models, Biological
Porphyria, Erythropoietic--genetics
Primary Cell Culture
RNA, Guide, CRISPR-Cas Systems--genetics
Recombinational DNA Repair
Tumor Suppressor Protein p53--genetics
Uroporphyrinogen III Synthetase--genetics
CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations. [electronic resource] - Nature communications Mar 2019 - 1136 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-09006-2 doi
CRISPR-Associated Protein 9--genetics
CRISPR-Cas Systems
Chromosome Deletion
Chromosomes, Human, Pair 10
Clustered Regularly Interspaced Short Palindromic Repeats
DNA--genetics
DNA Breaks, Double-Stranded
Deoxyribonuclease I--genetics
Fibroblasts--cytology
Gene Editing--methods
Genetic Therapy--methods
Genome, Human
HEK293 Cells
High-Throughput Nucleotide Sequencing
Humans
K562 Cells
Models, Biological
Porphyria, Erythropoietic--genetics
Primary Cell Culture
RNA, Guide, CRISPR-Cas Systems--genetics
Recombinational DNA Repair
Tumor Suppressor Protein p53--genetics
Uroporphyrinogen III Synthetase--genetics