Intact bioactivities and improved pharmacokinetic of the SL335-IFN-β-1a fusion protein that created by genetic fusion of SL335, a human anti-serum albumin fab, and human interferon-β. [electronic resource]
Producer: 20200217Description: 46-55 p. digitalISSN:- 1879-0542
- Animals
- CHO Cells
- Chromatography
- Cricetulus
- Glomerular Filtration Rate
- Half-Life
- Humans
- Immunoglobulin Fab Fragments -- genetics
- Immunotherapy -- methods
- Interferon beta-1a -- pharmacokinetics
- Interferon-beta -- genetics
- Macaca fascicularis
- Multiple Sclerosis -- immunology
- Protein Binding
- Protein Stability
- Rats
- Rats, Inbred Lew
- Receptor, Interferon alpha-beta -- metabolism
- Recombinant Fusion Proteins -- genetics
- Serum Albumin -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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