Intact bioactivities and improved pharmacokinetic of the SL335-IFN-β-1a fusion protein that created by genetic fusion of SL335, a human anti-serum albumin fab, and human interferon-β.

Ji, Soo-In

Intact bioactivities and improved pharmacokinetic of the SL335-IFN-β-1a fusion protein that created by genetic fusion of SL335, a human anti-serum albumin fab, and human interferon-β. [electronic resource] - Immunology letters 03 2019 - 46-55 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0542

10.1016/j.imlet.2019.01.009 doi


Animals
CHO Cells
Chromatography
Cricetulus
Glomerular Filtration Rate
Half-Life
Humans
Immunoglobulin Fab Fragments--genetics
Immunotherapy--methods
Interferon beta-1a--pharmacokinetics
Interferon-beta--genetics
Macaca fascicularis
Multiple Sclerosis--immunology
Protein Binding
Protein Stability
Rats
Rats, Inbred Lew
Receptor, Interferon alpha-beta--metabolism
Recombinant Fusion Proteins--genetics
Serum Albumin--immunology