A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. [electronic resource]
Producer: 20190219Description: 285 p. digitalISSN:- 2041-1723
- A549 Cells
- Animals
- Antiviral Agents -- pharmacology
- Cathepsin B -- metabolism
- Chlorocebus aethiops
- Clustered Regularly Interspaced Short Palindromic Repeats -- genetics
- Ebolavirus -- pathogenicity
- Fibroblasts
- Gene Knockout Techniques
- Hemorrhagic Fever, Ebola -- drug therapy
- Humans
- Mucolipidoses -- genetics
- Proprotein Convertases -- antagonists & inhibitors
- Protease Inhibitors -- pharmacology
- Pyrrolidines -- pharmacology
- Serine Endopeptidases -- metabolism
- Transferases (Other Substituted Phosphate Groups) -- antagonists & inhibitors
- Vero Cells
- Virus Internalization -- drug effects
- Whole Genome Sequencing
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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