A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus.
Flint, Mike
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. [electronic resource] - Nature communications 01 2019 - 285 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-018-08135-4 doi
A549 Cells
Animals
Antiviral Agents--pharmacology
Cathepsin B--metabolism
Chlorocebus aethiops
Clustered Regularly Interspaced Short Palindromic Repeats--genetics
Ebolavirus--pathogenicity
Fibroblasts
Gene Knockout Techniques
Hemorrhagic Fever, Ebola--drug therapy
Humans
Mucolipidoses--genetics
Proprotein Convertases--antagonists & inhibitors
Protease Inhibitors--pharmacology
Pyrrolidines--pharmacology
Serine Endopeptidases--metabolism
Transferases (Other Substituted Phosphate Groups)--antagonists & inhibitors
Vero Cells
Virus Internalization--drug effects
Whole Genome Sequencing
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. [electronic resource] - Nature communications 01 2019 - 285 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-018-08135-4 doi
A549 Cells
Animals
Antiviral Agents--pharmacology
Cathepsin B--metabolism
Chlorocebus aethiops
Clustered Regularly Interspaced Short Palindromic Repeats--genetics
Ebolavirus--pathogenicity
Fibroblasts
Gene Knockout Techniques
Hemorrhagic Fever, Ebola--drug therapy
Humans
Mucolipidoses--genetics
Proprotein Convertases--antagonists & inhibitors
Protease Inhibitors--pharmacology
Pyrrolidines--pharmacology
Serine Endopeptidases--metabolism
Transferases (Other Substituted Phosphate Groups)--antagonists & inhibitors
Vero Cells
Virus Internalization--drug effects
Whole Genome Sequencing