CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression. [electronic resource]
Producer: 20200226Description: 26 p. digitalISSN:- 2041-4889
- Animals
- Axin Protein -- metabolism
- CDX2 Transcription Factor -- genetics
- Caco-2 Cells
- Carcinogenesis -- metabolism
- Cell Cycle Checkpoints
- Cell Proliferation
- Colonic Neoplasms -- metabolism
- Cyclin D1 -- metabolism
- Female
- Gene Knockdown Techniques
- Glycogen Synthase Kinase 3 beta -- metabolism
- HT29 Cells
- Heterocyclic Compounds, 3-Ring -- pharmacology
- Heterografts
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Proto-Oncogene Proteins c-myc -- metabolism
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- Transfection
- Tumor Burden
- Wnt Proteins -- antagonists & inhibitors
- Wnt Signaling Pathway
- beta Catenin -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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