CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression.

Yu, Junhui

CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression. [electronic resource] - Cell death & disease 01 2019 - 26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-018-1263-9 doi


Animals
Axin Protein--metabolism
CDX2 Transcription Factor--genetics
Caco-2 Cells
Carcinogenesis--metabolism
Cell Cycle Checkpoints
Cell Proliferation
Colonic Neoplasms--metabolism
Cyclin D1--metabolism
Female
Gene Knockdown Techniques
Glycogen Synthase Kinase 3 beta--metabolism
HT29 Cells
Heterocyclic Compounds, 3-Ring--pharmacology
Heterografts
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Proto-Oncogene Proteins c-myc--metabolism
Pyridines--pharmacology
Pyrimidines--pharmacology
Transfection
Tumor Burden
Wnt Proteins--antagonists & inhibitors
Wnt Signaling Pathway
beta Catenin--antagonists & inhibitors