Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. [electronic resource]
Producer: 20200123Description: 377-385 p. digitalISSN:- 1521-009X
- Adult
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Biotransformation -- physiology
- Clopidogrel -- pharmacology
- Cross-Over Studies
- Cytochrome P-450 CYP2C8 -- metabolism
- Cytochrome P-450 CYP2C8 Inhibitors -- poisoning
- Drug Interactions -- physiology
- Female
- Gemfibrozil -- pharmacology
- Genotype
- Glucuronides -- pharmacology
- Humans
- Hypolipidemic Agents -- poisoning
- Loratadine -- analogs & derivatives
- Male
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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