Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
Itkonen, Matti K
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals 04 2019 - 377-385 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.118.084665 doi
Adult
Area Under Curve
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation--physiology
Clopidogrel--pharmacology
Cross-Over Studies
Cytochrome P-450 CYP2C8--metabolism
Cytochrome P-450 CYP2C8 Inhibitors--poisoning
Drug Interactions--physiology
Female
Gemfibrozil--pharmacology
Genotype
Glucuronides--pharmacology
Humans
Hypolipidemic Agents--poisoning
Loratadine--analogs & derivatives
Male
Young Adult
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals 04 2019 - 377-385 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.118.084665 doi
Adult
Area Under Curve
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation--physiology
Clopidogrel--pharmacology
Cross-Over Studies
Cytochrome P-450 CYP2C8--metabolism
Cytochrome P-450 CYP2C8 Inhibitors--poisoning
Drug Interactions--physiology
Female
Gemfibrozil--pharmacology
Genotype
Glucuronides--pharmacology
Humans
Hypolipidemic Agents--poisoning
Loratadine--analogs & derivatives
Male
Young Adult