The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. [electronic resource]
Producer: 20190820Description: 4 p. digitalISSN:- 1868-7083
- Cell Line, Tumor
- DNA Breaks, Double-Stranded -- drug effects
- Drug Resistance, Neoplasm
- Epigenesis, Genetic
- HCT116 Cells
- Histone-Lysine N-Methyltransferase
- Histones -- metabolism
- Humans
- Methylation
- Methyltransferases -- antagonists & inhibitors
- Phosphorylation
- Prognosis
- RNA, Small Interfering -- pharmacology
- Recombinational DNA Repair
- Rectal Neoplasms -- metabolism
- Small Molecule Libraries -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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