The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.

Kari, Vijayalakshmi

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. [electronic resource] - Clinical epigenetics 01 2019 - 4 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1868-7083

10.1186/s13148-018-0601-1 doi


Cell Line, Tumor
DNA Breaks, Double-Stranded--drug effects
Drug Resistance, Neoplasm
Epigenesis, Genetic
HCT116 Cells
Histone-Lysine N-Methyltransferase
Histones--metabolism
Humans
Methylation
Methyltransferases--antagonists & inhibitors
Phosphorylation
Prognosis
RNA, Small Interfering--pharmacology
Recombinational DNA Repair
Rectal Neoplasms--metabolism
Small Molecule Libraries--pharmacology