Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism. [electronic resource]
Producer: 20190109Description: e0006873 p. digitalISSN:- 1935-2735
- Animals
- DNA Replication -- drug effects
- Enhancer of Zeste Homolog 2 Protein -- antagonists & inhibitors
- Enzyme Inhibitors -- pharmacology
- Female
- Gene Expression Regulation -- drug effects
- Indazoles -- pharmacology
- Locomotion -- drug effects
- Male
- Metabolic Networks and Pathways -- drug effects
- Microscopy, Electron, Scanning
- Oviposition -- drug effects
- Pyridones -- pharmacology
- RNA, Untranslated -- metabolism
- Schistosoma mansoni -- drug effects
- Survival Analysis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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