Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.

Pereira, Adriana S A

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism. [electronic resource] - PLoS neglected tropical diseases 10 2018 - e0006873 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1935-2735

10.1371/journal.pntd.0006873 doi


Animals
DNA Replication--drug effects
Enhancer of Zeste Homolog 2 Protein--antagonists & inhibitors
Enzyme Inhibitors--pharmacology
Female
Gene Expression Regulation--drug effects
Indazoles--pharmacology
Locomotion--drug effects
Male
Metabolic Networks and Pathways--drug effects
Microscopy, Electron, Scanning
Oviposition--drug effects
Pyridones--pharmacology
RNA, Untranslated--metabolism
Schistosoma mansoni--drug effects
Survival Analysis