Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish. [electronic resource]
Producer: 20200304Description: 189-206 p. digitalISSN:- 1432-0738
- Amino Acid Sequence
- Animals
- Anthozoa -- chemistry
- Anticonvulsants -- pharmacology
- Heme Oxygenase (Decyclizing) -- metabolism
- Locomotion
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Neuroprotective Agents -- pharmacology
- Nitric Oxide Synthase Type II -- metabolism
- Oxidopamine -- adverse effects
- PC12 Cells
- Pentylenetetrazole -- adverse effects
- Peptides -- chemical synthesis
- Protein Structure, Tertiary
- Rats
- Reactive Oxygen Species -- metabolism
- Voltage-Gated Sodium Channel Blockers -- pharmacology
- Voltage-Gated Sodium Channels -- metabolism
- Zebrafish
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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