Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.

Liao, Qiwen

Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish. [electronic resource] - Archives of toxicology 01 2019 - 189-206 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-0738

10.1007/s00204-018-2334-5 doi


Amino Acid Sequence
Animals
Anthozoa--chemistry
Anticonvulsants--pharmacology
Heme Oxygenase (Decyclizing)--metabolism
Locomotion
Molecular Docking Simulation
Molecular Dynamics Simulation
Neuroprotective Agents--pharmacology
Nitric Oxide Synthase Type II--metabolism
Oxidopamine--adverse effects
PC12 Cells
Pentylenetetrazole--adverse effects
Peptides--chemical synthesis
Protein Structure, Tertiary
Rats
Reactive Oxygen Species--metabolism
Voltage-Gated Sodium Channel Blockers--pharmacology
Voltage-Gated Sodium Channels--metabolism
Zebrafish