Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. [electronic resource]
Producer: 20191113Description: 14697 p. digitalISSN:- 2045-2322
- ADAM10 Protein -- metabolism
- Amyloid Precursor Protein Secretases -- metabolism
- Cell Membrane -- metabolism
- Extracellular Matrix -- metabolism
- HEK293 Cells
- Humans
- Ligands
- Low Density Lipoprotein Receptor-Related Protein-1 -- metabolism
- Mass Spectrometry
- Membrane Proteins -- metabolism
- Protein Transport -- physiology
- Proteomics
- Secretory Pathway -- physiology
- Tissue Inhibitor of Metalloproteinase-3 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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