Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.
Scilabra, Simone D
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. [electronic resource] - Scientific reports 10 2018 - 14697 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/s41598-018-32910-4 doi
ADAM10 Protein--metabolism
Amyloid Precursor Protein Secretases--metabolism
Cell Membrane--metabolism
Extracellular Matrix--metabolism
HEK293 Cells
Humans
Ligands
Low Density Lipoprotein Receptor-Related Protein-1--metabolism
Mass Spectrometry
Membrane Proteins--metabolism
Protein Transport--physiology
Proteomics
Secretory Pathway--physiology
Tissue Inhibitor of Metalloproteinase-3--metabolism
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. [electronic resource] - Scientific reports 10 2018 - 14697 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/s41598-018-32910-4 doi
ADAM10 Protein--metabolism
Amyloid Precursor Protein Secretases--metabolism
Cell Membrane--metabolism
Extracellular Matrix--metabolism
HEK293 Cells
Humans
Ligands
Low Density Lipoprotein Receptor-Related Protein-1--metabolism
Mass Spectrometry
Membrane Proteins--metabolism
Protein Transport--physiology
Proteomics
Secretory Pathway--physiology
Tissue Inhibitor of Metalloproteinase-3--metabolism