RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. [electronic resource]
Producer: 20190507Description: 1064-1073 p. digitalISSN:- 1476-4679
- Animals
- Antineoplastic Agents -- pharmacology
- Biomarkers, Tumor -- genetics
- Cell Line, Tumor
- Enzyme Inhibitors -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Genetic Predisposition to Disease
- Guanosine Triphosphate -- metabolism
- HEK293 Cells
- Humans
- Mice, Inbred BALB C
- Mice, Nude
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Mutation
- Neoplasms -- drug therapy
- Neurofibromin 1 -- genetics
- Phenotype
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- antagonists & inhibitors
- Proto-Oncogene Proteins B-raf -- genetics
- Proto-Oncogene Proteins p21(ras) -- genetics
- SOS1 Protein -- metabolism
- Signal Transduction
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
- raf Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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