Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour. [electronic resource]
Producer: 20190731Description: 682-697 p. digitalISSN:- 1090-2139
- Animals
- Anti-Anxiety Agents -- pharmacology
- Brain -- metabolism
- Embryo, Mammalian
- Female
- Hyperkinesis -- physiopathology
- Macrophages -- metabolism
- Male
- Mice
- Microglia -- drug effects
- Organic Chemicals -- pharmacology
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor -- antagonists & inhibitors
- Sex Factors
- Weight Gain -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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