Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour.

Rosin, Jessica M

Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour. [electronic resource] - Brain, behavior, and immunity 10 2018 - 682-697 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1090-2139

10.1016/j.bbi.2018.07.023 doi


Animals
Anti-Anxiety Agents--pharmacology
Brain--metabolism
Embryo, Mammalian
Female
Hyperkinesis--physiopathology
Macrophages--metabolism
Male
Mice
Microglia--drug effects
Organic Chemicals--pharmacology
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor--antagonists & inhibitors
Sex Factors
Weight Gain--physiology