Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma. [electronic resource]
Producer: 20190916Description: 2877-2893 p. digitalISSN:- 1558-8238
- Animals
- Bortezomib -- pharmacology
- Cell Line, Tumor
- Cell Proliferation
- Drug Resistance, Neoplasm
- Gene Knockdown Techniques
- Glucuronidase -- metabolism
- Humans
- Mice
- Mice, Inbred NOD
- Models, Biological
- Multiple Myeloma -- drug therapy
- NF-kappa B -- metabolism
- NIMA-Related Kinases -- antagonists & inhibitors
- Prognosis
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors -- pharmacology
- Protein Binding
- Protein Stability
- Signal Transduction
- Ubiquitin-Specific Peptidase 7 -- antagonists & inhibitors
- Ubiquitination
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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