Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.
Franqui-Machin, Reinaldo
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma. [electronic resource] - The Journal of clinical investigation 07 2018 - 2877-2893 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI98765 doi
Animals
Bortezomib--pharmacology
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
Gene Knockdown Techniques
Glucuronidase--metabolism
Humans
Mice
Mice, Inbred NOD
Models, Biological
Multiple Myeloma--drug therapy
NF-kappa B--metabolism
NIMA-Related Kinases--antagonists & inhibitors
Prognosis
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors--pharmacology
Protein Binding
Protein Stability
Signal Transduction
Ubiquitin-Specific Peptidase 7--antagonists & inhibitors
Ubiquitination
Xenograft Model Antitumor Assays
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma. [electronic resource] - The Journal of clinical investigation 07 2018 - 2877-2893 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI98765 doi
Animals
Bortezomib--pharmacology
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
Gene Knockdown Techniques
Glucuronidase--metabolism
Humans
Mice
Mice, Inbred NOD
Models, Biological
Multiple Myeloma--drug therapy
NF-kappa B--metabolism
NIMA-Related Kinases--antagonists & inhibitors
Prognosis
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors--pharmacology
Protein Binding
Protein Stability
Signal Transduction
Ubiquitin-Specific Peptidase 7--antagonists & inhibitors
Ubiquitination
Xenograft Model Antitumor Assays