Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. [electronic resource]
Producer: 20190916Description: 2927-2943 p. digitalISSN:- 1558-8238
- Animals
- Antineoplastic Agents -- pharmacokinetics
- Biomarkers, Tumor -- antagonists & inhibitors
- Brentuximab Vedotin
- Cell Line, Tumor
- Female
- Humans
- Immunoconjugates -- pharmacokinetics
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Nude
- Mice, SCID
- Microfilament Proteins
- Neoplasm Proteins -- antagonists & inhibitors
- Neoplasms -- drug therapy
- Receptors, Cell Surface -- antagonists & inhibitors
- Receptors, Peptide -- antagonists & inhibitors
- Stromal Cells -- drug effects
- Tumor Microenvironment -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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