Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.
Szot, Christopher
Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. [electronic resource] - The Journal of clinical investigation 07 2018 - 2927-2943 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI120481 doi
Animals
Antineoplastic Agents--pharmacokinetics
Biomarkers, Tumor--antagonists & inhibitors
Brentuximab Vedotin
Cell Line, Tumor
Female
Humans
Immunoconjugates--pharmacokinetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Mice, SCID
Microfilament Proteins
Neoplasm Proteins--antagonists & inhibitors
Neoplasms--drug therapy
Receptors, Cell Surface--antagonists & inhibitors
Receptors, Peptide--antagonists & inhibitors
Stromal Cells--drug effects
Tumor Microenvironment--drug effects
Xenograft Model Antitumor Assays
Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. [electronic resource] - The Journal of clinical investigation 07 2018 - 2927-2943 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI120481 doi
Animals
Antineoplastic Agents--pharmacokinetics
Biomarkers, Tumor--antagonists & inhibitors
Brentuximab Vedotin
Cell Line, Tumor
Female
Humans
Immunoconjugates--pharmacokinetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Mice, SCID
Microfilament Proteins
Neoplasm Proteins--antagonists & inhibitors
Neoplasms--drug therapy
Receptors, Cell Surface--antagonists & inhibitors
Receptors, Peptide--antagonists & inhibitors
Stromal Cells--drug effects
Tumor Microenvironment--drug effects
Xenograft Model Antitumor Assays