Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ. [electronic resource]
Producer: 20180619Description: 2351-2368 p. digitalISSN:- 1421-9778
- Animals
- Astrocytes -- drug effects
- Cells, Cultured
- Glucose -- immunology
- HMGB1 Protein -- immunology
- Infarction, Middle Cerebral Artery -- drug therapy
- Male
- Neuroprotection -- drug effects
- Neuroprotective Agents -- therapeutic use
- PPAR gamma -- immunology
- Pioglitazone
- Pyroptosis -- drug effects
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- immunology
- Receptor for Advanced Glycation End Products -- immunology
- Reperfusion Injury -- drug therapy
- Signal Transduction -- drug effects
- Thiazolidinediones -- therapeutic use
- rac1 GTP-Binding Protein -- immunology
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Publication Type: Journal Article
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