Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ.

Xia, Pingping

Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ. [electronic resource] - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018 - 2351-2368 p. digital

Publication Type: Journal Article

1421-9778

10.1159/000488183 doi


Animals
Astrocytes--drug effects
Cells, Cultured
Glucose--immunology
HMGB1 Protein--immunology
Infarction, Middle Cerebral Artery--drug therapy
Male
Neuroprotection--drug effects
Neuroprotective Agents--therapeutic use
PPAR gamma--immunology
Pioglitazone
Pyroptosis--drug effects
Rats, Sprague-Dawley
Reactive Oxygen Species--immunology
Receptor for Advanced Glycation End Products--immunology
Reperfusion Injury--drug therapy
Signal Transduction--drug effects
Thiazolidinediones--therapeutic use
rac1 GTP-Binding Protein--immunology