Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway. [electronic resource]
Producer: 20180827Description: 53 p. digitalISSN:- 1743-8977
- A549 Cells
- Aluminum Oxide -- toxicity
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Disease Progression
- Dose-Response Relationship, Drug
- Humans
- Inflammation Mediators -- metabolism
- Inhalation Exposure -- adverse effects
- Lung -- drug effects
- Male
- Metal Nanoparticles -- toxicity
- Mice, Inbred C57BL
- Phosphorylation
- Pneumonia -- chemically induced
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- metabolism
- Pulmonary Disease, Chronic Obstructive -- chemically induced
- Pulmonary Emphysema -- chemically induced
- RNA-Binding Proteins -- metabolism
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Time Factors
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Publication Type: Journal Article
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