Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. [electronic resource]
Producer: 20180926Description: 197-209 p. digitalISSN:- 1558-1497
- Alzheimer Disease -- complications
- Amyloid Precursor Protein Secretases -- metabolism
- Amyloid beta-Peptides -- immunology
- Animals
- Benzylidene Compounds -- pharmacology
- Brain -- metabolism
- Cells, Cultured
- Cognitive Dysfunction -- drug therapy
- Disease Models, Animal
- Humans
- Mice, Transgenic
- Microglia -- immunology
- Neuroblastoma -- metabolism
- Phagocytosis -- drug effects
- Pyridines -- pharmacology
- Rats
- Tumor Cells, Cultured
- alpha7 Nicotinic Acetylcholine Receptor -- agonists
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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