Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. (Record no. 27825420)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02279 a2200625 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517185622.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201809s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1558-1497 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1016/j.neurobiolaging.2017.10.021 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Takata, Kazuyuki |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20180926 |
| 245 00 - TITLE STATEMENT | |
| Title | Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Neurobiology of aging |
| Date of publication, distribution, etc. | 02 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197-209 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Alzheimer Disease |
| General subdivision | complications |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Amyloid Precursor Protein Secretases |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Amyloid beta-Peptides |
| General subdivision | immunology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzylidene Compounds |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Brain |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cells, Cultured |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cognitive Dysfunction |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Disease Models, Animal |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Transgenic |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Microglia |
| General subdivision | immunology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neuroblastoma |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phagocytosis |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumor Cells, Cultured |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | alpha7 Nicotinic Acetylcholine Receptor |
| General subdivision | agonists |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amamiya, Takahide |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mizoguchi, Hiroaki |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kawanishi, Shohei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kuroda, Eriko |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kitamura, Risa |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ito, Aina |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saito, Yuki |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tawa, Manami |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagasawa, Tomofumi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Okamoto, Haruka |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sugino, Yuko |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Takegami, Shigehiko |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kitade, Tatsuya |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Toda, Yuki |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kem, William R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kitamura, Yoshihisa |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shimohama, Shun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashihara, Eishi |
| 773 0# - HOST ITEM ENTRY | |
| Title | Neurobiology of aging |
| Related parts | vol. 62 |
| -- | p. 197-209 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1016/j.neurobiolaging.2017.10.021">https://doi.org/10.1016/j.neurobiolaging.2017.10.021</a> |
| Public note | Available from publisher's website |
No items available.