Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition. [electronic resource]
Producer: 20180611ISSN:- 2047-9980
- Animals
- Antineoplastic Agents -- toxicity
- Cardiotoxicity
- Cells, Cultured
- Dose-Response Relationship, Drug
- Echocardiography
- ErbB Receptors -- antagonists & inhibitors
- Erlotinib Hydrochloride -- toxicity
- Fatty Acids -- metabolism
- Female
- Gene Expression Profiling
- Heart -- diagnostic imaging
- Heart Diseases -- chemically induced
- Indoles -- toxicity
- Mice
- Molecular Targeted Therapy
- Myocardial Contraction -- drug effects
- Myocardium -- enzymology
- Myocytes, Cardiac -- drug effects
- Niacinamide -- analogs & derivatives
- Oxidation-Reduction
- Phenylurea Compounds -- toxicity
- Protein Interaction Maps
- Protein Kinase Inhibitors -- toxicity
- Proteomics
- Pyrroles -- toxicity
- Rats, Sprague-Dawley
- STAT3 Transcription Factor -- antagonists & inhibitors
- Signal Transduction
- Sorafenib
- Sunitinib
- Time Factors
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Publication Type: Comparative Study; Journal Article
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