Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition.

Stuhlmiller, Timothy J

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition. [electronic resource] - Journal of the American Heart Association Oct 2017

Publication Type: Comparative Study; Journal Article

2047-9980

10.1161/JAHA.117.006635 doi


Animals
Antineoplastic Agents--toxicity
Cardiotoxicity
Cells, Cultured
Dose-Response Relationship, Drug
Echocardiography
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride--toxicity
Fatty Acids--metabolism
Female
Gene Expression Profiling
Heart--diagnostic imaging
Heart Diseases--chemically induced
Indoles--toxicity
Mice
Molecular Targeted Therapy
Myocardial Contraction--drug effects
Myocardium--enzymology
Myocytes, Cardiac--drug effects
Niacinamide--analogs & derivatives
Oxidation-Reduction
Phenylurea Compounds--toxicity
Protein Interaction Maps
Protein Kinase Inhibitors--toxicity
Proteomics
Pyrroles--toxicity
Rats, Sprague-Dawley
STAT3 Transcription Factor--antagonists & inhibitors
Signal Transduction
Sorafenib
Sunitinib
Time Factors