SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling. [electronic resource]
Producer: 20171023Description: 1154-1163 p. digitalISSN:- 1532-1827
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Squamous Cell -- metabolism
- Cell Proliferation -- drug effects
- Cyclin A -- drug effects
- Cyclin D1 -- drug effects
- Cyclin-Dependent Kinase 2 -- drug effects
- Cyclin-Dependent Kinase 4 -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- drug effects
- Cyclin-Dependent Kinase Inhibitor p27 -- drug effects
- Down-Regulation
- ErbB Receptors -- antagonists & inhibitors
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Head and Neck Neoplasms -- metabolism
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- In Vitro Techniques
- Mice
- Mice, Nude
- Molecular Docking Simulation
- Purines -- pharmacology
- Signal Transduction
- Squamous Cell Carcinoma of Head and Neck
- Up-Regulation
- Xenograft Model Antitumor Assays
- cdc25 Phosphatases -- drug effects
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Publication Type: Journal Article
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