Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. [electronic resource]
Producer: 20171002Description: 1046-1054 p. digitalISSN:- 1546-170X
- Acetanilides -- pharmacology
- Adenocarcinoma, Clear Cell -- genetics
- Animals
- Apoptosis -- drug effects
- Azepines -- pharmacology
- Carcinoma, Endometrioid -- genetics
- Carcinosarcoma -- genetics
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chromatography, Liquid
- Cullin Proteins -- metabolism
- Drug Resistance, Neoplasm
- Endometrial Neoplasms -- genetics
- Epigenesis, Genetic
- Female
- Heterocyclic Compounds, 3-Ring -- pharmacology
- Humans
- Immunoblotting
- Immunohistochemistry
- Immunoprecipitation
- Male
- Mass Spectrometry
- Mice, Nude
- Molecular Targeted Therapy
- Mutation
- Neoplasm Transplantation
- Neoplasms, Cystic, Mucinous, and Serous -- genetics
- Nuclear Proteins -- antagonists & inhibitors
- Prostatic Neoplasms -- genetics
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- RNA-Binding Proteins -- antagonists & inhibitors
- Repressor Proteins -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors -- antagonists & inhibitors
- Triazoles -- pharmacology
- Ubiquitination
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Publication Type: Journal Article
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