Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova, Hana

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. [electronic resource] - Nature medicine 09 2017 - 1046-1054 p. digital

Publication Type: Journal Article

1546-170X

10.1038/nm.4372 doi


Acetanilides--pharmacology
Adenocarcinoma, Clear Cell--genetics
Animals
Apoptosis--drug effects
Azepines--pharmacology
Carcinoma, Endometrioid--genetics
Carcinosarcoma--genetics
Cell Cycle Proteins
Cell Line, Tumor
Cell Proliferation--drug effects
Chromatography, Liquid
Cullin Proteins--metabolism
Drug Resistance, Neoplasm
Endometrial Neoplasms--genetics
Epigenesis, Genetic
Female
Heterocyclic Compounds, 3-Ring--pharmacology
Humans
Immunoblotting
Immunohistochemistry
Immunoprecipitation
Male
Mass Spectrometry
Mice, Nude
Molecular Targeted Therapy
Mutation
Neoplasm Transplantation
Neoplasms, Cystic, Mucinous, and Serous--genetics
Nuclear Proteins--antagonists & inhibitors
Prostatic Neoplasms--genetics
Protein Serine-Threonine Kinases--antagonists & inhibitors
RNA-Binding Proteins--antagonists & inhibitors
Repressor Proteins--genetics
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors--antagonists & inhibitors
Triazoles--pharmacology
Ubiquitination