Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction. [electronic resource]
Producer: 20170926Description: 6924-6941 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- administration & dosage
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Down-Regulation
- Doxorubicin -- pharmacology
- Drug Design
- G-Quadruplexes
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Ligands
- Mice, Inbred BALB C
- Molecular Docking Simulation
- NM23 Nucleoside Diphosphate Kinases -- antagonists & inhibitors
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-myc -- antagonists & inhibitors
- Pyrroles -- administration & dosage
- Quinazolines -- administration & dosage
- Quinazolinones -- administration & dosage
- Structure-Activity Relationship
- Transcription, Genetic
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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