Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.
Wang, Yu-Qing
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction. [electronic resource] - Journal of medicinal chemistry 08 2017 - 6924-6941 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b00421 doi
Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Down-Regulation
Doxorubicin--pharmacology
Drug Design
G-Quadruplexes
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Ligands
Mice, Inbred BALB C
Molecular Docking Simulation
NM23 Nucleoside Diphosphate Kinases--antagonists & inhibitors
Promoter Regions, Genetic
Proto-Oncogene Proteins c-myc--antagonists & inhibitors
Pyrroles--administration & dosage
Quinazolines--administration & dosage
Quinazolinones--administration & dosage
Structure-Activity Relationship
Transcription, Genetic
Xenograft Model Antitumor Assays
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction. [electronic resource] - Journal of medicinal chemistry 08 2017 - 6924-6941 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b00421 doi
Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Down-Regulation
Doxorubicin--pharmacology
Drug Design
G-Quadruplexes
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Ligands
Mice, Inbred BALB C
Molecular Docking Simulation
NM23 Nucleoside Diphosphate Kinases--antagonists & inhibitors
Promoter Regions, Genetic
Proto-Oncogene Proteins c-myc--antagonists & inhibitors
Pyrroles--administration & dosage
Quinazolines--administration & dosage
Quinazolinones--administration & dosage
Structure-Activity Relationship
Transcription, Genetic
Xenograft Model Antitumor Assays