Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. [electronic resource]
Producer: 20170926Description: 813-824.e4 p. digitalISSN:- 2451-9448
- AMP-Activated Protein Kinase Kinases
- AMP-Activated Protein Kinases -- antagonists & inhibitors
- Allosteric Regulation
- Binding Sites
- Catalytic Domain
- Cell-Free System
- Enzyme Activation -- drug effects
- HEK293 Cells
- HeLa Cells
- Humans
- Indans -- pharmacology
- Indoles -- chemistry
- Mutagenesis, Site-Directed
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- chemistry
- Phosphorylation -- drug effects
- Protein Isoforms -- genetics
- Protein Serine-Threonine Kinases -- metabolism
- Pyrimidines -- pharmacology
- Sorafenib
- Sulfonamides -- chemistry
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article
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