Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Ross, Fiona A

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. [electronic resource] - Cell chemical biology Jul 2017 - 813-824.e4 p. digital

Publication Type: Journal Article

2451-9448

10.1016/j.chembiol.2017.05.021 doi


AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases--antagonists & inhibitors
Allosteric Regulation
Binding Sites
Catalytic Domain
Cell-Free System
Enzyme Activation--drug effects
HEK293 Cells
HeLa Cells
Humans
Indans--pharmacology
Indoles--chemistry
Mutagenesis, Site-Directed
Niacinamide--analogs & derivatives
Phenylurea Compounds--chemistry
Phosphorylation--drug effects
Protein Isoforms--genetics
Protein Serine-Threonine Kinases--metabolism
Pyrimidines--pharmacology
Sorafenib
Sulfonamides--chemistry
src-Family Kinases--antagonists & inhibitors