Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. [electronic resource]
Producer: 20171121Description: 4145-4152 p. digitalISSN:- 1464-3391
- Cell Line, Tumor
- Drug Discovery
- Drug Screening Assays, Antitumor
- HEK293 Cells
- Humans
- Leucine-tRNA Ligase -- metabolism
- Mass Spectrometry -- methods
- Mechanistic Target of Rapamycin Complex 1 -- antagonists & inhibitors
- Phosphorylation
- Proton Magnetic Resonance Spectroscopy
- Ribosomal Protein S6 Kinases -- metabolism
- Sulfonic Acids -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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