NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report. [electronic resource]
Producer: 20170808Description: 1457-1461 p. digitalISSN:- 1524-4636
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Apolipoproteins E -- deficiency
- Atherosclerosis -- genetics
- Carotid Arteries -- drug effects
- Carotid Artery Diseases -- genetics
- Cells, Cultured
- Cholesterol -- pharmacology
- Crystallization
- Dendritic Cells -- drug effects
- Diet, Western
- Disease Models, Animal
- Female
- Furans
- Genetic Predisposition to Disease
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Indenes
- Inflammasomes -- antagonists & inhibitors
- Intercellular Adhesion Molecule-1 -- genetics
- Interleukin-1beta -- metabolism
- Lipopolysaccharides -- pharmacology
- Macrophages -- drug effects
- Mice, Inbred C57BL
- Mice, Knockout
- NLR Family, Pyrin Domain-Containing 3 Protein -- antagonists & inhibitors
- Necrosis
- Phenotype
- Plaque, Atherosclerotic
- RNA, Messenger -- genetics
- Signal Transduction -- drug effects
- Sulfonamides
- Sulfones -- pharmacology
- Time Factors
- Vascular Cell Adhesion Molecule-1 -- genetics
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Publication Type: Journal Article
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