The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. [electronic resource]
Producer: 20170828Description: 744-752 p. digitalISSN:- 1529-2916
- Adolescent
- Adult
- Animals
- Autoimmune Diseases -- genetics
- Autoimmunity -- genetics
- Blotting, Southern
- Cardiovirus Infections -- genetics
- Diabetes Mellitus, Experimental -- genetics
- Diabetes Mellitus, Type 1 -- genetics
- Encephalomyocarditis virus -- immunology
- Female
- Genetic Predisposition to Disease
- HEK293 Cells
- Humans
- Immunoblotting
- Interferon Type I -- immunology
- Interferon-Induced Helicase, IFIH1 -- genetics
- Male
- Mice
- Middle Aged
- Polymorphism, Single Nucleotide
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Virus Diseases -- genetics
- Young Adult
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Publication Type: Journal Article
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