Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors. [electronic resource]
Producer: 20170911Description: 3080-3087 p. digitalISSN:- 1097-0142
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal, Humanized -- therapeutic use
- Antineoplastic Agents -- therapeutic use
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Carcinoma, Ovarian Epithelial
- Carcinoma, Renal Cell -- drug therapy
- Diarrhea -- chemically induced
- Disease Progression
- Dose-Response Relationship, Drug
- Endometrial Neoplasms -- drug therapy
- Fatigue -- chemically induced
- Female
- Humans
- Hypophosphatemia -- chemically induced
- Immunoconjugates -- therapeutic use
- Keratitis -- chemically induced
- Kidney Neoplasms -- drug therapy
- Lung Neoplasms -- drug therapy
- Male
- Maximum Tolerated Dose
- Maytansine -- analogs & derivatives
- Middle Aged
- Neoplasms -- drug therapy
- Neoplasms, Glandular and Epithelial -- drug therapy
- Ovarian Neoplasms -- drug therapy
- Vision Disorders -- chemically induced
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Publication Type: Clinical Trial, Phase I; Journal Article
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