Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors.

Moore, Kathleen N

Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors. [electronic resource] - Cancer Aug 2017 - 3080-3087 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article

1097-0142

10.1002/cncr.30736 doi


Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Humanized--therapeutic use
Antineoplastic Agents--therapeutic use
Carcinoma, Non-Small-Cell Lung--drug therapy
Carcinoma, Ovarian Epithelial
Carcinoma, Renal Cell--drug therapy
Diarrhea--chemically induced
Disease Progression
Dose-Response Relationship, Drug
Endometrial Neoplasms--drug therapy
Fatigue--chemically induced
Female
Humans
Hypophosphatemia--chemically induced
Immunoconjugates--therapeutic use
Keratitis--chemically induced
Kidney Neoplasms--drug therapy
Lung Neoplasms--drug therapy
Male
Maximum Tolerated Dose
Maytansine--analogs & derivatives
Middle Aged
Neoplasms--drug therapy
Neoplasms, Glandular and Epithelial--drug therapy
Ovarian Neoplasms--drug therapy
Vision Disorders--chemically induced