Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. [electronic resource]
Producer: 20170821Description: 2479-2483 p. digitalISSN:- 1464-3405
- Animals
- Brain -- metabolism
- Humans
- Inhibitory Concentration 50
- Muscarinic Antagonists -- chemical synthesis
- Protein Binding
- Pyrimidines -- chemical synthesis
- Rats
- Receptor, Muscarinic M4 -- antagonists & inhibitors
- Receptors, Muscarinic -- chemistry
- Recombinant Proteins -- biosynthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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