Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. (Record no. 27098659)

MARC details
000 -LEADER
fixed length control field 01649 a2200433 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250517151300.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201708s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1464-3405
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.bmcl.2017.04.009
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Bender, Aaron M
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20170821
245 00 - TITLE STATEMENT
Title Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Bioorganic & medicinal chemistry letters
Date of publication, distribution, etc. 06 2017
300 ## - PHYSICAL DESCRIPTION
Extent 2479-2483 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Inhibitory Concentration 50
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Muscarinic Antagonists
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Binding
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Pyrimidines
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Receptor, Muscarinic M4
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Receptors, Muscarinic
General subdivision chemistry
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Recombinant Proteins
General subdivision biosynthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Structure-Activity Relationship
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Weiner, Rebecca L
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Luscombe, Vincent B
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Cho, Hyekyung P
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Niswender, Colleen M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Engers, Darren W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bridges, Thomas M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Conn, P Jeffrey
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lindsley, Craig W
773 0# - HOST ITEM ENTRY
Title Bioorganic & medicinal chemistry letters
Related parts vol. 27
-- no. 11
-- p. 2479-2483
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1016/j.bmcl.2017.04.009">https://doi.org/10.1016/j.bmcl.2017.04.009</a>
Public note Available from publisher's website

No items available.